New implant biocompatibility improvement technology developed in Siberia
17 Sep '21
A new method of improving the surface properties of implants has been developed in Tomsk, in Siberia. At the core of the approach are special microcapsules loaded with medicinal substances. This is expected to help better control the release of drugs, said the lead developers from the Tomsk Polytechnic University (TPU) and their colleagues from Sweden, Germany, and the UK.
This approach to surface modification is reported to have been offered for the first time in global research history. Current results of the study have been published in English in Materials Chemistry and Physics.
In their experiments, the researchers deposited onto titanium implants special polyelectrolyte microcapsules, loaded with both porous calcium carbonate microparticles and a special anti-inflammatory drug called dexamethasone. Thus the surface of implants – or titanium alloy scaffolds, to be more precise – was functionalized.
A scaffold is a biomaterial structure that serves as a substrate and a guide for human tissue repair and regeneration. In addition, it is a system of delivering target substances with given and/or controllable properties which steps up and facilitates regenerative processes.
In their work, the scientists made sure the microcapsules would dissolve in a natural way, thus guaranteeing the prolongation of medicinal effect. According to one of the lead researchers, Maria Surmeneva of TPU, “it’s the scaffold itself that innovates the whole process; each scaffold has been made using additive technologies, which ensures well-developed porosity on the surface of a scaffold – an achievement that has eased strong bond formation between microparticles and the surface.”